Association between intraoperative alactic base excess and postoperative acute kidney injury after liver transplantation: a retrospective cohort study
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Background
Acute kidney injury (AKI) is a common complication after liver transplantation (LT). Alactic base excess (ABE) reflects the metabolic component of acid–base disturbances not attributable to lactate and has been associated with kidney dysfunction in other clinical settings. We evaluated the association between intraoperative ABE and postoperative AKI after LT.
Methods
We conducted a retrospective cohort study of adult patients undergoing LT. ABE was calculated from standard base excess and lactate obtained from the last intraoperative arterial blood gas analysis. The primary outcome was creatinine-based AKI occurring within the first 7 postoperative days according to Kidney Disease: Improving Global Outcomes criteria. The association between ABE and AKI was estimated using modified Poisson regression with robust variance, adjusted for age, sex, body mass index, MELD score, cold ischemia time, and anhepatic phase duration. A post hoc exploratory analysis evaluated severe AKI, defined as KDIGO stages 2–3.
Results
Seventy patients were included, of whom 32 (45.7%) developed AKI. ABE values were lower among patients who developed AKI than among those who did not (median, −1.15 vs 0.75 mmol/L; Hodges–Lehmann location shift, −1.60 mmol/L; 95%CI, −2.80 to −0.20). After multivariable adjustment, ABE was not independently associated with AKI (aRR, 0.91; 95%CI, 0.82–1.01; p=0.07). Severe AKI occurred in 14 patients (20.0%), and ABE was not independently associated with severe AKI (aRR, 0.98; 95%CI, 0.78–1.23; p=0.87). Sensitivity analyses yielded consistent findings.
Conclusions
A single intraoperative ABE measurement was not independently associated with postoperative AKI or severe AKI after LT. Serial measurements across different phases of transplantation may better characterize the potential relationship between ABE dynamics and postoperative kidney injury.
