Seroprevalence of viral hemorrhagic fevers and arboviral infections among febrile patients in Forest Guinea

  1. Fara Raymond Koundouno
  2. Youssouf Sidibe
  3. Hugo Soubrier
  4. Karifa Kourouma
  5. Soua Koulemou
  6. Tamba Elie Millimouno
  7. Fernand MBemba Tolno
  8. Saa Lucien Millimono
  9. Kekoura Ifono
  10. Faya Moriba Kamano
  11. Mamadou Dioulde Barry
  12. Bely Sonomy
  13. Mariame Traore
  14. Kaba Keita
  15. Mette Hinrichs
  16. Beate Becker Ziaja
  17. Emily Victoria Nelson
  18. Christine Jacobsen
  19. Anke Thielebein
  20. Lisa Oestereich
  21. Meike Pahlmann
  22. Beatriz Escudero-Perez
  23. Ralf Krumkamp
  24. Stephan Guenther
  25. Moussa Kolie
  26. Kaba Keita
  27. Sira Helene Guilavogui
  28. NFaly Magassouba
  29. Sanaba Boumbaly
  30. Giuditta Annibaldis
  31. Sophie Duraffour
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Abstract

Between 2017 and 2024, routine diagnostics surveillance in Guinea detected several confirmed viral hemorrhagic fever (VHF) cases among febrile patients. To assess exposure to Lassa virus and other viral pathogens, we conducted a retrospective cross-sectional seroprevalence study in Forest Guinea (Guéckédou and N′Zérékoré). Lassa virus seroprevalence was 56.0% in the Guéckédou study group and 29.8% in the N′Zérékoré study group. Seropositivity increased with age in both study groups, suggesting cumulative exposure. Samples from Guéckédou laboratory were also tested for other pathogens, and antibodies against Marburg virus (5.8%), Zika virus (5.4%) and Crimean-Congo haemorrhagic fever virus (1.2%) were detected.

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  1. Version published to 10.64898/2026.09.02.26362016 on medRxiv