Relation of Self-Reported Race and Genetic Ancestry to Hypertension Prevalence Among Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Background
The imprecision of current metrics to capture the complex genetic admixture and racial identity among Hispanic/Latino individuals in the United States (US) is a concern. We examined the relationship of self-reported race and genetic ancestry with hypertension (HTN) among Hispanics/Latinos.
Methods
Cross-sectional study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), including 10,586 Hispanic/Latino unrelated adults. Genetic ancestry: West African (AA), Amerindian (AI), and European (EA). Self-reported race: White, Black, Native American, or Multiple/Missing ( More than one race or Unknown/Not reported/Refused ). HTN: systolic (SBP) ≥130 mmHg, diastolic blood pressure (DBP) ≥80 mmHg, and/or use of HTN medications. Age- and sex adjusted models were used.
Results
Self-reported race was White (38·6%), Black (3·6%), Native American (4·1%), and Multiple/Missing (53·7%), with Unknown/Not reported/Refused representing 32·7%. Black and White Hispanics/Latinos had the greatest AA (55·7%) and EA (69·3%) ancestries, respectively. Each 10% AA increase was associated with OR 1·15, SBP beta +0.9 mmHg, and DBP beta +0.7 mmHg. Conversely, each 10% AI increase was associated with OR 0·83, SBP beta -0·4 mmHg, and DBP beta -0·6 mmHg. HTN prevalence was highest among those with Black race or in the highest AA quantile (45·6% and 48·0%, respectively), and lowest among those with Native American race or in the highest AI quantile (37·6% and 26·7%, respectively).
Conclusion
One-third of Hispanics/Latinos did not self-report race. Black or White self-reporting race did somewhat relate to AA or EA ancestry, respectively. HTN profiles were related to self-reported race and genetic ancestry in this admixed population.
