From Data Curation to Risk Reporting: A Pipeline for Polygenic Risk Scores

Polygenic risk scores (PRS) have emerged as a powerful tool for quantifying genetic susceptibility to complex traits and diseases. However, their calculation and interpretation require standardized data curation, robust statistical methods, and clear reporting strategies. In this work, we present an integrated pipeline designed to address these challenges. The pipeline begins with the construction of a curated genotype/phenotype database derived from public repositories, ensuring that only phenotypes with appropriate metadata, statistical distributions, and ethical suitability are retained. The final dataset comprises 2,346 phenotypes covering 38,256,468 unique SNPs. These phenotypes serve as the final analytical units for PRS calculation, risk stratification, and individual-level interpretation. The generated reports integrate sample-level results, phenotype categorization, risk classification, study references, and variant tables, providing a structured and interpretable output for end users. Together, the curated database and reporting framework establish a comprehensive toolbox for PRS analysis, enhancing reproducibility, transparency, and usability in both research and clinical contexts.