Gradient-guided adapter merging for neuroimaging vision-language models

Automated interpretation of neuroimaging studies requires simultaneous assessment of multiple imaging evidence variables, each tied to distinct anatomical structures. Vision-language models (VLMs) offer a unified framework for multi-task analysis, but adapting pre-trained VLMs remains challenging. Full fine-tuning is computationally prohibitive, and joint multi-task training requires simultaneous access to all task data, which is often infeasible in clinical settings. Although model merging enables multi-task composition without joint re-training, existing methods focus on post-hoc algorithms with limited extension to VLMs and minimal application to neuroimaging. Here, we present GRadient-guided Adapter Merging (GRAM), a layer-selective low-rank adaptation (LoRA)-based fine-tuning and merging framework for multi-task neuroimaging visual question-answering (VQA). GRAM uses a gradient ratio that contrasts class-specific gradients to identify task-discriminative layers, and applies subspace-constrained projected gradient descent to restrict LoRA updates to directions consistent with the geometry of the pre-trained model. We leveraged a structured VQA benchmark, developed from the National Alzheimer’s Coordinating Center (NACC) dataset, that pairs multisequence brain MRI studies with question-answer pairs across clinically relevant imaging evidence variables. Experiments on the VQA benchmark showed that GRAM outperformed or matched all-layer LoRA fine-tuning and a standard merging baseline while reducing inter-task interference during merging, and approached or surpassed the performance of joint multi-task training without joint re-training.