Development of a Core Outcome Set for Mild Cognitive Impairment (MCI-COS): Recommendations from a multistakeholder Delphi consensus study
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INTRODUCTION
Meaningful research into mild cognitive impairment (MCI) is limited by trial outcomes which are heterogeneous and may not always be important to patients. We developed a core outcome set (COS) for the evaluation of interventions in patients with MCI (MCI-COS).
METHODS
A scoping umbrella review and interviews with stakeholders (patients, family members, and professionals) determined a longlist of potential outcomes. A modified two-round Delphi study and consensus meeting agreed the final MCI-COS.
RESULTS
A ten-item COS was identified: cognitive functioning (non-memory), memory, mental health and wellbeing, social functioning/relationships, quality of life, everyday functioning and independence, biomarkers of brain health, progression to dementia, general/physical health, and sleep.
DISCUSSION
Embedding the COS into clinical trials and practice will reduce outcome heterogeneity and encourage transparent reporting of outcomes prioritised by stakeholders, beyond those typically included in trials for MCI.
