Association of daily physical activity, handgrip strength and visceral adiposity with mortality, cardiovascular events and cancers in Japanese individuals with diabetes
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Aims
This study examined the associations of body composition and daily physical activity with mortality, CV events and cancer in individuals with diabetes.
Methods
This prospective cohort study included individuals with diabetes treated at a specialised clinic in Japan between January 2018 and March 2023. Body composition, including visceral adipose tissue (VAT), was assessed by bioelectrical impedance analysis. Daily physical activity was evaluated using the non-exercise activity thermogenesis (NEAT) questionnaire, and handgrip strength (HGS) was measured by dynamometry. Cox proportional hazards models were used to assess associations with mortality, CV events, and cancer.
Results
Among 2,024 participants (mean age 63.0 years, BMI 24.6 kg/m², HbA1c 7.8%), NEAT score, HGS and VAT were not independently associated with all-cause mortality. Higher VAT was associated with increased cancer risk (HR = 1.288; 95% CI, 1.008–1.646; p = 0.043). Higher HGS was inversely associated with CV event risk (HR = 0.955; 95% CI, 0.925–0.986; p = 0.005). NEAT score was not associated with any outcome.
Conclusions
Higher VAT was associated with increased cancer risk, whereas higher HGS was associated with a lower rate of CV events. Incorporating body composition and HGS assessments into clinical practice may provide additional prognostic information in individuals with diabetes.
