Urinary Biomarkers of Consumer Product Chemical Exposure and Wrist-Worn Ambient Light Exposure Patterns in U.S. Adults: NHANES 2011-2014

We examined associations between a 15-component urinary biomarker mixture index related to consumer product chemical exposure and wrist-worn ambient light exposure metrics in U.S. adults. Using National Health and Nutrition Examination Survey (NHANES) 2011-2014, we studied adults aged 20 years or older with valid wrist accelerometry and urinary chemical biomarkers ( N = 1,666). Eight wrist-worn ambient light exposure metrics were derived from hour-level ActiGraph GT3X+ data. A standardized urinary biomarker mixture index was used in survey-weighted linear regression adjusted for age, sex, race/ethnicity, poverty-income ratio, education, BMI, cotinine, sleep duration, and season. Higher urinary biomarker mixture index was associated with greater morning light (beta = 0.54; 95% CI: 0.14, 0.94), greater nighttime light (beta = 0.55; 95% CI: 0.21, 0.89), and earlier light centroid timing (beta = −1.37 h; 95% CI: −2.14, −0.59) after false discovery rate (FDR) correction. In a weighted sensitivity analysis using quantile g-computation, associations were directionally similar. No sex modification was observed (all interaction P > .23). Higher consumer product chemical mixture burden co-occurred with earlier-timed wrist-worn ambient light exposure patterns, consistent with shared behavioral, occupational, and environmental determinants.