Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments
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We report here a method for the chemical synthesis of Fmoc-protected α-hydroxyglyine (α-OH-Gly) dipeptides. Our method features operational simplicity and is compatible with protecting groups for peptide synthesis. Utility is then demonstrated through substitution at the α-OH-Gly position to yield myriad non-natural amino acid-containing dipeptide fragments.
