Number Needed to Vaccinate with a Novel Tuberculosis Vaccine to Prevent Tuberculosis in High-Risk Populations, United States
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We estimated the number needed to vaccinate (NNV) with an M72/AS01 E -like vaccine to prevent one tuberculosis case in U.S. high-risk groups. Targeted vaccination of Mycobacterium tuberculosis –infected persons yielded NNVs of 217 (persons with HIV) to 2,486 (U.S.-born), within the range of established adult vaccines.
Summary line
Targeted vaccination of Mycobacterium tuberculosis -infected high-risk persons with an M72/AS01 E -like vaccine could prevent one tuberculosis case per 217 (HIV) to 2,486 (U.S.-born) persons vaccinated, within the range of established adult vaccines.
