COVID ‐19 in New South Wales children during 2021: severity and clinical spectrum
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SciScore for 10.1101/2021.12.27.21268348: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: 27 Approvals: PAEDS surveillance is approved by the SCHN human research ethics committee (HREC; study number 2019/ETH06144) including a waiver of consent for collection of case data.
Consent: 27 Approvals: PAEDS surveillance is approved by the SCHN human research ethics committee (HREC; study number 2019/ETH06144) including a waiver of consent for collection of case data.Sex as a biological variable not detected. Randomization We identified a simple random sample of children cared for in the community by the SCHN virtual care service (stratified by calendar month; sampled to achieve 2:1 ratio of ambulatory to admitted cases). Blinding not detected. Power Analysis not detected. Table 2: Resources
SciScore for 10.1101/2021.12.27.21268348: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: 27 Approvals: PAEDS surveillance is approved by the SCHN human research ethics committee (HREC; study number 2019/ETH06144) including a waiver of consent for collection of case data.
Consent: 27 Approvals: PAEDS surveillance is approved by the SCHN human research ethics committee (HREC; study number 2019/ETH06144) including a waiver of consent for collection of case data.Sex as a biological variable not detected. Randomization We identified a simple random sample of children cared for in the community by the SCHN virtual care service (stratified by calendar month; sampled to achieve 2:1 ratio of ambulatory to admitted cases). Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources PAEDS surveillance nurses actively reviewed clinical and laboratory records of children with SARS-CoV-2 infection or paediatric inflammatory multi-system syndrome temporally associated with SARS-CoV-2 (PIMS-TS, also known as multi-system inflammatory syndrome in children, MIS-C) and liaised with clinical teams to identify and subsequently monitor eligible children presenting to participating hospitals, resulting in comprehensive, individual case data collated within a national electronic database (REDCap, hosted at the University of Sydney) that facilitated analyses and reporting. REDCapsuggested: (REDCap, RRID:SCR_003445)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:We did not identify a high risk of admission in those with a history of immunosuppression (also in keeping with previous studies);30,32 although an important caveat to this finding is that there were relatively few of these admissions among our cohort of >17,000 children. Due to the large number of children managed by virtual care, another limitation of our study was that we were unable to characterise all the demographic and medical co-morbid and clinical features among cases of all the children under this model of care; but selected a random sample that was likely representative of the larger cohort of children. Our data revealed that obesity was associated with ICU admission, but this risk factor could not be evaluated in our multivariable model due to sample size. A history of asthma or viral induced wheeze was not associated with an increased risk of hospitalisation, yet other chronic respiratory conditions were - including chronic lung disease and obstructive sleep apnoea. This finding is consistent in the literature,3,4,6 and may be secondary to the TH2 predominant inflammation seen in asthma, with its associated IL-4, IL-5 and IL-13 response – the latter of which has been shown to downregulate the expression of SARS-CoV-2 host cell receptors.33 Our data revealed there are two dominant paediatric age cohorts at increased risk of medical admission due to SARS-CoV-2 infection. These are infants (<6 months) for whom a history of prematurity was an important risk factor fo...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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