Humoral Immune Response in Inactivated SARS-CoV-2 Vaccine: When Should a Booster Dose be Administered?

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Abstract

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  1. SciScore for 10.1101/2021.07.08.21260194: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsConsent: Blood samples were taken after the participants had been informed about the study and had signed an informed consent form.
    Sex as a biological variablenot detected.
    RandomizationThe participants were randomly selected from a list of 3,000 health workers.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Immunogenicity assessments: The project aimed to measure anti-SARS-CoV-2 S-RBD (anti-S-RBD) immunoglobulin G (IgG), total anti-spike and anti-nucleocapsid immunoglobulin IgG antibody concentrations in the same individuals repetitively in the first, third and sixth months.
    anti-SARS-CoV-2
    suggested: None
    anti-S-RBD
    suggested: None
    IgG), total anti-spike and anti-nucleocapsid immunoglobulin IgG
    suggested: None
    Software and Algorithms
    SentencesResources
    Statistical analyses: Data were examined using the SPSS 22 statistical analyses package (2013,
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.