Efficacy and safety of tocilizumab in the management of COVID-19: a systematic review and meta-analysis of observational studies
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SciScore for 10.1101/2021.01.27.21250599: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources , anti-histaminic (cetirizine,), antibiotics (cephalosporins), corticosteroids (prednisolone, methylprednisolone), monoclonal antibodies (tocilizumab, imatinib) [16]. anti-histaminic (cetirizine,),suggested: NoneSoftware and Algorithms Sentences Resources Methods: The electronic search was performed using PubMed, Scopus, CENTRAL, and Google scholar to identify the retrospective observational reports. PubMedsuggested: (PubMed, RRID:SCR_004846)Further, the pre-print servers such as Research … SciScore for 10.1101/2021.01.27.21250599: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources , anti-histaminic (cetirizine,), antibiotics (cephalosporins), corticosteroids (prednisolone, methylprednisolone), monoclonal antibodies (tocilizumab, imatinib) [16]. anti-histaminic (cetirizine,),suggested: NoneSoftware and Algorithms Sentences Resources Methods: The electronic search was performed using PubMed, Scopus, CENTRAL, and Google scholar to identify the retrospective observational reports. PubMedsuggested: (PubMed, RRID:SCR_004846)Further, the pre-print servers such as Research Square, bioRxiv.org, and medRxiv were also considered while searching the grey literature. bioRxivsuggested: (bioRxiv, RRID:SCR_003933)An example of a search strategy using PUBMED and Google Scholar has been highlighted in Annexure 1. Google Scholarsuggested: (Google Scholar, RRID:SCR_008878)2.3 Quality assessment and Risk of Bias analysis for included studies All the included studies were subjected to the quality assessment using the Newcastle-Ottawa scale and also evaluated for risk of bias using the Cochrane Collaboration tool to assess The Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I). 2.4. Cochrane Collaboration toolsuggested: NoneStatistical analysis Review Manager (RevMan, version 5.3; Nordic Cochrane Centre RevMansuggested: (RevMan, RRID:SCR_003581)[Cochrane Collaboration], Copenhagen, Denmark; 2014) shall be used to analyze the data. Cochrane Collaborationsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04346355 Terminated Efficacy of Early Administration of Tocilizumab in COVID-19 … NCT04331808 Active, not recruiting CORIMUNO-19 - Tocilizumab Trial - TOCI (CORIMUNO-TOCI) NCT04356937 Completed Efficacy of Tocilizumab on Patients With COVID-19 NCT04320615 Completed A Study to Evaluate the Safety and Efficacy of Tocilizumab i… NCT02735707 Recruiting Randomized, Embedded, Multifactorial Adaptive Platform Trial… NCT04372186 Active, not recruiting A Study to Evaluate the Efficacy and Safety of Tocilizumab i… NCT04317092 Active, not recruiting Tocilizumab in COVID-19 Pneumonia (TOCIVID-19) NCT04445272 Completed Clinical Trial to Evaluate the Effectiveness and Safety of T… NCT04377659 Active, not recruiting Tocilizumab for Prevention of Respiratory Failure in Patient… NCT04330638 Active, not recruiting Treatment of COVID-19 Patients With Anti-interleukin Drugs NCT04345445 Not yet recruiting Study to Evaluate the Efficacy and Safety of Tocilizumab Ver… NCT04372602 Recruiting Duvelisib to Combat COVID-19 NCT0442553810 Trial number did not resolve on clinicaltrials.gov. Is the number correct? NA Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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