Role of serological rapid antibody test in the management of possible COVID-19 cases

  1. Fatma Yıldırım
  2. Pinar Yildiz Gulhan
  3. Özlem Ercen Diken
  4. Aylin Capraz
  5. Meltem Simsek
  6. Berna Botan Yildirim
  7. Muhammet Ridvan Taysi
  8. Sakine Yilmaz Ozturk
  9. Nurcan Demirtas
  10. Julide Ergil
  11. Adem Dirican
  12. Tugce Uzar
  13. Irem Karaman
  14. Sevket Ozkaya

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Abstract

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  1. Version published to 10.5493/wjem.v11.i4.44
  2. ScreenIT

    SciScore for 10.1101/2020.09.13.20193615: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    We retrospectively analyzed the patients with COVID-19 who have at least two consecutive PCR test results were negative for COVID-19 and specific antibodies against SARS-CoV-2 were positive.
    SARS-CoV-2
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study has several limitations, including low sample size, the lack of control group and its retrospective nature, however; ideal research conditions are often difficult to be establish during a pandemic situation. In conclusion, our study remarks the importance of antibody testing in patients which could not be proved with PCR testing for several reasons; such as false negative results or viral clearance of the upper respiratory tract. Even though there is no specific treatment for COVID-19, it is highly important to confirm the diagnosis of highly suspected cases and to prevent further contamination since the retard of diagnosis aided the treatment. Our study demonstrates the feasibility of COVID-19 diagnosis based on rapid-card test for constantly PCR-negative suspected COVID-19 patients. We suggest that detection of antibodies against SARS-CoV-2 with rapid-card test should be included in the diagnostic algorithm in PCR-negative patients with COVID-19 pneumonia.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.09.13.20193615v1 on medRxiv