Characteristics of COVID-19 Recurrence: A Systematic Review and Meta-Analysis
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SciScore for 10.1101/2020.09.05.20189134: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable For each study, the following information was extracted: first author’s name, country, study type, number of recurrence cases and discharged patients, the sample used for reverse transcription polymerase chain reaction (RT-PCR), mean or median age (years), number of males, females, and cases underlying any chronic diseases (including chronic obstructive pulmonary disease, cardiovascular disease, hypertension, diabetes, liver or kidney disease, and cancer), times from disease onset to admission, from admission to discharge, and from discharge to … SciScore for 10.1101/2020.09.05.20189134: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable For each study, the following information was extracted: first author’s name, country, study type, number of recurrence cases and discharged patients, the sample used for reverse transcription polymerase chain reaction (RT-PCR), mean or median age (years), number of males, females, and cases underlying any chronic diseases (including chronic obstructive pulmonary disease, cardiovascular disease, hypertension, diabetes, liver or kidney disease, and cancer), times from disease onset to admission, from admission to discharge, and from discharge to positive conversion (days). Table 2: Resources
Software and Algorithms Sentences Resources An electronic search of PubMed and Embase was conducted for English language studies published from the inception until September 17, 2020. PubMedsuggested: (PubMed, RRID:SCR_004846)Embasesuggested: (EMBASE, RRID:SCR_001650)All the statistical analyses were performed using STATA 14.0 software. STATAsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, several limitations need to be mentioned. First, 80% of the included studies (33/41) with 78% recurrence cases (435/556) come from the Chinese population, which may reduce the availability to generalize the pooled estimates into other populations. Second, heterogeneity for the prevalence of recurrence cases was substantially presented among studies. The different characteristics, discharge criteria, and the test samples used among study populations included in this meta-analysis may have contributed to the heterogeneity. Last, all the estimates in the current study are based on aggregate data from published articles. Failure to obtain individual patient data may lead to bias due to the lack of full exploration and adjustment for patient characteristics 61. In summary, an estimate of 15% of COVID-19 patients was repositive after discharge. Among them, 39% of subjects were underlying comorbidity. It is recommended to pay attention to follow-up patients after discharge by closely monitoring their RT-PCR results, even if they have been in quarantine for 14 days. Further studies are needed to determine factors associated with positive RT-PCR in COVID-19 patients after discharge.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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