Chest Radiograph Severity and Its Association With Outcomes in Subjects With COVID-19 Presenting to the Emergency Department
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SciScore for 10.1101/2021.10.31.21265672: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Cleveland Clinic Institutional Review Board (IRB) exempted the study from IRB approval (FLA 20-038). Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are several limitations associated with our study. The time-frame during which the study was performed did not allow for adjustment for anti-viral treatments …
SciScore for 10.1101/2021.10.31.21265672: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Cleveland Clinic Institutional Review Board (IRB) exempted the study from IRB approval (FLA 20-038). Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are several limitations associated with our study. The time-frame during which the study was performed did not allow for adjustment for anti-viral treatments (such as dexamethasone and remdesivir) which have been shown to decrease severity of radiographic edema (26) as these were introduced later during the study period within the healthcare system (late August-September). We were also not able to adjust for any variables other than those obtained at baseline when performing the longitudinal analyses, raising the question of whether other organ failure outside of the pulmonary system (renal) and fluid status have contributed to radiographic deterioration that is not directly associated with COVID-19 pulmonary disease. Lastly, while the study is a multi-center study across multiple hospitals and states in the United States, practices and procedures early in the pandemic were often institution-based and not necessarily guided by the Centers for Disease Control and Prevention and/or the World Health Organization. As such, institutional standards of treatment may not have been reflective of other healthcare systems around the same time period. Despite these limitations, we excluded patients for which there was incomplete data that would otherwise require imputation and potentially affect our analyses. Instead, the study protocol structured the CXR sampling periods to provide early, standardized meaningful clinical data that may assist clinicians in prognostication and decis...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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