Prevalence and Clinical Correlates of COVID-19 Outbreak Among Health Care Workers in a Tertiary Level Hospital in Delhi

  1. Ankit Khurana
  2. GP Kaushal
  3. Rishi Gupta
  4. Vansh Verma
  5. Kabir Sharma
  6. PM Kohli

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Abstract

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  1. Version published to 10.3844/ajidsp.2021.107.119
  2. ScreenIT

    SciScore for 10.1101/2020.07.21.20159301: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: Various epidemiological parameters along with symptoms, co-morbidities, and preventive strategies adopted by healthcare workers were recorded after obtaining due consent.
    IRB: Statistical significance was kept at p < 0.05. 2.2 Ethical approval: Data collection and analysis of cases was part of a continuing public health outbreak investigation and was thus considered exempt from institutional review board approval.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    SPSS v23 (IBM Corp.) was used for statistical analysis.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The same group of French authors (Gautret et al) have published synergy between azithromycin and hydroxychloroquine based on faster viral clearance when a combination of the two drugs was used.(37) The limitation of their findings were - no control arm and only patients with mild disease were included. (38) Mahevas did a retrospective analysis of 181 patients from 4 hospitals of which 84 who had taken hydroxychloroquine and 79 did not. The authors found no benefit and approximately 10% needed to discontinue hydroxychloroquine due to QTC prolongation issue. (39) Tang conducted a multi-centric RCT of 150 hospitalized patients with COVID and found that hydroxychloroquine doesn’t lead to faster viral clearance. Post hoc analysis controlling for use of other antivirals found early symptom relief with hydroxychloroquine and faster improvement in CRP. (40) Magagnoli retrospectively analyzed 368 males. They found that in their non-randomized study found that risk of death was higher with hydroxychloroquine group. (41) 4.5 Mask usage: A recent study on influenza referenced above shows no difference lab confirmed influenza with use of either N95 or surgical mask, influenza virus like COVID is an RNA virus with similar infectivity.(42) Leung assessed the use of masks in transmission of respiratory viruses including Influenza, non COVID Coronaviruses, and Rhinoviruses between 2013 to 2016. They included 246 participants with respiratory symptoms who had confirmed respiratory virus and ra...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.07.21.20159301v1 on medRxiv