Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population
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Abstract
The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data show that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After only one vaccine dose, the neutralization capacity expanded to all tested variants in pre-exposed individuals. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose did induce similar neutralizing antibodies against the Delta as against the authentic strain. However, even after two doses, this capacity only expanded to the Epsilon variant.
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SciScore for 10.1101/2021.10.25.21265422: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources cPass SARS-CoV-2 Neutralization Antibody Detection Assay: To determine the neutralizing activity of antibodies against SARS-CoV-2, we used a surrogate viral neutralization test (C-Pass GenScript sVNT, Piscataway NJ, USA) according to the manufacturer’s instructions [9-11]. SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources Statistical Methods: Statistical analyses were performed using GraphPad Prism 7.0 software (GraphPad Software, San Diego, CA, USA). GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_0027…SciScore for 10.1101/2021.10.25.21265422: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources cPass SARS-CoV-2 Neutralization Antibody Detection Assay: To determine the neutralizing activity of antibodies against SARS-CoV-2, we used a surrogate viral neutralization test (C-Pass GenScript sVNT, Piscataway NJ, USA) according to the manufacturer’s instructions [9-11]. SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources Statistical Methods: Statistical analyses were performed using GraphPad Prism 7.0 software (GraphPad Software, San Diego, CA, USA). GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:We are aware of the limitations of our study, including the small sample size and lack of cellular immunity characterization. The waning of natural or vaccine-elicited immunity remains a possibility outside the follow-up period carried out in this work. However, our results, despite being obtained from a population of different genetic backgrounds, agree with the current ongoing scenario (October 2021) in the United Kingdom (UK). A rampant increase in Delta variant circulation, up 35% over the two previous weeks, has been observed after all restrictions were lifted in summer 2021 [26]. However, taking into account the high number of cases naturally exposed to the virus and a high vaccination rate in the UK [27], as it would be anticipated by our results, the daily deaths are a tenth of what they were in the prior wave [26, 28]. Considering our findings, a more challenging scenario would be a predominance of other variants like Alpha, Beta, Gamma or Kappa, showing limited neutralization after full vaccination with the mRNA COVID-19 vaccines. To our knowledge, this is the first study conducted in a Hispanic/Latino population impacted by COVID-19, and our findings are a significant contribution to the still lacking population-based studies concerning virus-population dynamics in the setting of vaccination and shed light on the design of the second generation COVID-19 vaccines.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
Results from scite Reference Check: We found no unreliable references.
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