A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe

  1. Alberto Borobia
  2. Antonio Carcas
  3. Francisco Arnalich
  4. Rodolfo Álvarez-Sala
  5. Jaime Monserrat-Villatoro
  6. Manuel Quintana
  7. Juan Figueira
  8. Rosario Torres Santos-Olmo
  9. Julio García-Rodríguez
  10. Alberto Martín-Vega
  11. Antonio Buño
  12. Elena Ramírez
  13. Gonzalo Martínez-Alés
  14. Nicolás García-Arenzana
  15. M. Núñez
  16. Milagros Martí-de-Gracia
  17. Francisco Moreno Ramos
  18. Francisco Reinoso-Barbero
  19. Alejandro Martin-Quiros
  20. Angélica Rivera Núñez
  21. Jesús Mingorance
  22. Carlos Carpio Segura
  23. Daniel Prieto Arribas
  24. Esther Rey Cuevas
  25. Concepción Prados Sánchez
  26. Juan Rios
  27. Miguel Hernán
  28. Jesús Frías
  29. José Arribas
  30. on behalf of the COVID@HULP Working Group

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Abstract

Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.

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  1. ScreenIT

    SciScore for 10.1101/2020.04.29.20080853: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The study was approved by the Research Ethics Committee of La Paz University Hospital (PI-4072) and by the Spanish Agency of Medicines and Medical Devices (HUL-AIN-2020-01) and was registered in the European Union Electronic Register of Post-Authorization Studies (EUPAS34331).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    At present there are no clinical trial data supporting that any of these treatments improve outcomes of COVIID-19 This study has a number of limitations. First, the data were collected from various databases, both manually and automatically. The data included manually in the eCRF was monitored and curated. Second, we did not conduct a follow-up of the patients after discharge. Third our reported mortality rates might change when our full cohort of hospitalized patients is analyzed In summary, this study provides initial data on the clinical and laboratory features and outcomes of patients hospitalized with COVID-19 infection in a large teaching hospital in Madrid during the peak of the epidemic

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.3390/jcm9061733
  3. Version published to 10.1101/2020.04.29.20080853v2 on medRxiv
  4. Version published to 10.1101/2020.04.29.20080853v1 on medRxiv