Emerging Potential of Metabolomics in Thyroid Cancer—A Comprehensive Review

Thyroid cancer is a very common endocrine system malignancy. Nevertheless, a dearth of precise markers makes it challenging to apply precision medicine to thyroid cancer. The limitations of standard diagnosis techniques (fine-needle aspiration biopsy), such as indeterminate cases and inaccuracies in distinguishing between different types of cancers, lead to unnecessary surgeries and thus warrant the development of more discriminatory biomarkers to improve the accuracy of existing diagnostic and prognostic techniques. Moreover, individualized therapies for thyroid cancer are necessary to avoid overtreatment of indolent lesions and undertreatment of high-risk progressive disease. As thyroid cancer metabolic signatures are associated with disease aggressiveness and responsiveness to therapy, metabolomics has been recently used for diagnostic and prognostic biomarker discovery. This strategy has enabled the detection of several metabolites from tissue samples or biofluids to facilitate the classification of disease aggressiveness and to potentially assist in individualized therapies. In this review, we summarize the utilization and potential of metabolomics in thyroid cancer.