Evolving FATE: A New Lens on the Pathogenesis and Management of Feline Cardiogenic Arterial Thromboembolism

Feline cardiogenic arterial thromboembolism (FATE) remains one of the most devastating complications of feline cardiomyopathies, with high mortality and recurrence rates. Despite its clinical importance, significant knowledge gaps persist in our understanding of FATE’s pathogenesis and optimal management strategies. Our review aims to address these gaps by providing a comprehensive overview of the current understanding of FATE, including disease mechanisms, risk factors, emerging diagnostics, and preventative strategies. Importantly, we identify key areas such as immunothrombosis, procoagulant platelets, platelet heterogeneity, and altered fibrinolysis where future research may yield novel biomarkers and therapeutic targets to improve outcomes in affected feline patients.