SARS-CoV-2 Seroprevalence and Profiles Among Convalescents in Sichuan Province, China
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Abstract
Objectives: To explore and understand the SARS-CoV-2 seroprevalence of convalescents, the association between antibody levels and demographic factors, and the seroepidemiology of convalescents of COVID-19 till March 2021.
Methods: We recruited 517 voluntary COVID-19 convalescents in Sichuan Province and collected 1,707 serum samples till March 2021. Then we reported the seroprevalence and analyzed the associated factors.
Results: Recent travel history was associated with IgM levels. Convalescents who had recent travel history were less likely to be IgM antibody negative [OR = 0.232, 95% CI: (0.128, 0.420)]. Asymptomatic cases had, approximately, twice the odds of being IgM antibody negative compared with symptomatic cases [OR = 2.583, 95% CI: (1.554, 4.293)]. Participants without symptoms were less likely to be IgG seronegative than those with symptoms [OR = 0.511, 95% CI: (0.293, 0.891)]. Convalescents aged 40–59 were less likely to be IgG seronegative than those aged below 20 [OR = 0.364, 95% CI: (0.138, 0.959)]. The duration of positive IgM antibodies persisted 365 days while the IgG persisted more than 399 days.
Conclusions: Our findings suggested that recent travel history might be associated with the antibody levels of IgM, while age could be associated with the antibody levels of IgG. Infection type could be associated with both antibody levels of IgM and IgG that declined quicker in asymptomatic cases.
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SciScore for 10.1101/2021.05.04.21256355: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: All subjects voluntarily joined serological researches with informed consent.
Field Sample Permit: All 363 serum samples were detected by the Institute of Microbiology and Analysis. Detection of IgG and IgM: Non-anticoagulant specimens (intravenous blood collection) were collected for all subjects, 3mL for children (<5 years), and 5mL for others.
IRB: Ethical approval: The survey was discussed with the Ethics Committee of Center for Disease Control and Prevention in Sichuan Province, who reviewed the content.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources We considered … SciScore for 10.1101/2021.05.04.21256355: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: All subjects voluntarily joined serological researches with informed consent.
Field Sample Permit: All 363 serum samples were detected by the Institute of Microbiology and Analysis. Detection of IgG and IgM: Non-anticoagulant specimens (intravenous blood collection) were collected for all subjects, 3mL for children (<5 years), and 5mL for others.
IRB: Ethical approval: The survey was discussed with the Ethics Committee of Center for Disease Control and Prevention in Sichuan Province, who reviewed the content.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources We considered the antibody results as outcome, and it was divided into two groups (positive or negative), previous studies have found that gender and age were related to the results of the antibody[15]. antibody[15suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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