Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19
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SciScore for 10.1101/2020.04.17.046938: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Differentially expressed genes in bronchial epithelial cells infected with SARS-CoV-2: In order to identify essential differentially expressed genes in SARS-CoV-2 infected versus non-infected epithelial cells, we re-analyzed the publicly available transcriptomic dataset (GSE147507) recently uploaded to the Gene Expression Omnibus (GEO) (11). Gene Expression Omnibussuggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)Principle component analysis and Heatmap clustering were … SciScore for 10.1101/2020.04.17.046938: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Differentially expressed genes in bronchial epithelial cells infected with SARS-CoV-2: In order to identify essential differentially expressed genes in SARS-CoV-2 infected versus non-infected epithelial cells, we re-analyzed the publicly available transcriptomic dataset (GSE147507) recently uploaded to the Gene Expression Omnibus (GEO) (11). Gene Expression Omnibussuggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)Principle component analysis and Heatmap clustering were generated, and differentially expressed genes (DEGs) were identified using LIMMA algorithm built in AltAnalyze software. LIMMAsuggested: (LIMMA, RRID:SCR_010943)Graphical visualization of the gene was made using the Metascape online tool for gene ontology (http://metascape.org) (13). Metascapesuggested: (Metascape, RRID:SCR_016620)Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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