Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
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SciScore for 10.1101/2020.04.07.029488: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources Reagents and Chemicals: Doxorubicin, Paclitaxel, monoclonal anti-Glo1 antibody (rat), anti-Rat IgG (whole molecule)–Biotin conjugate, D-Lactic dehydrogenase were purchased from Sigma-Aldrich (Poole, Dorset, UK). anti-Glo1suggested: (Sigma-Aldrich Cat# SAB1100241, RRID:AB_10606523)anti-Rat IgGsuggested: NoneD-Lactic dehydrogenasesuggested: NoneExperimental Models: Cell Lines Sentences Resources The HEK293 cell line was purchased from the American Tissue … SciScore for 10.1101/2020.04.07.029488: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources Reagents and Chemicals: Doxorubicin, Paclitaxel, monoclonal anti-Glo1 antibody (rat), anti-Rat IgG (whole molecule)–Biotin conjugate, D-Lactic dehydrogenase were purchased from Sigma-Aldrich (Poole, Dorset, UK). anti-Glo1suggested: (Sigma-Aldrich Cat# SAB1100241, RRID:AB_10606523)anti-Rat IgGsuggested: NoneD-Lactic dehydrogenasesuggested: NoneExperimental Models: Cell Lines Sentences Resources The HEK293 cell line was purchased from the American Tissue Culture Collection (ATCC, Virginia, USA). HEK293suggested: CLS Cat# 300192/p777_HEK293, RRID:CVCL_0045)Software and Algorithms Sentences Resources Sequences of reviewed proteins of the human proteome, 18,821 – excluding fetal proteins, were obtained from the UniProtKB database (www.uniprot.org). UniProtKBsuggested: (UniProtKB, RRID:SCR_004426)To identify similar arginines residues in SARS-CoV and MERS proteins, we used the Clustal Omega software on-line (Madeira et al., 2019). Clustal Omegasuggested: (Clustal Omega, RRID:SCR_001591)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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