Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2020.06.14.20129957: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Data processing and statistical analysis: Nanostring mRNA counts were first normalized using the NanoStringNorm function in the statistical analysis software R on log2 transformed data. NanoStringNormsuggested: (NanoStringNorm, RRID:SCR_003382)Differential analysis was conducted using linear models in the limma package (R/Bioconductor) after adjusting for the gender difference. limmasuggested: (LIMMA, RRID:SCR_010943)Results from OddPub: We did not detect open data. We also did …
SciScore for 10.1101/2020.06.14.20129957: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Data processing and statistical analysis: Nanostring mRNA counts were first normalized using the NanoStringNorm function in the statistical analysis software R on log2 transformed data. NanoStringNormsuggested: (NanoStringNorm, RRID:SCR_003382)Differential analysis was conducted using linear models in the limma package (R/Bioconductor) after adjusting for the gender difference. limmasuggested: (LIMMA, RRID:SCR_010943)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Whilst the study provides several differential gene expression patterns in non-smokers, smokers and COPD/IPF, there is a limitation regarding the small sample size and smoking history. Nonetheless the study is valuable in terms of approach and identifying a good number targets, which needs thorough characterizations in future studies.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-
-
