Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology

  1. Jose Gómez-Rial
  2. Maria José Currás-Tuala
  3. Irene Rivero-Calle
  4. Alberto Gómez-Carballa
  5. Miriam Cebey-López
  6. Carmen Rodríguez-Tenreiro
  7. Ana Dacosta-Urbieta
  8. Carmen Rivero-Velasco
  9. Nuria Rodríguez-Núñez
  10. Rocio Trastoy-Pena
  11. Javier Rodríguez-García
  12. Antonio Salas
  13. Federico Martinón-Torres

Reviewed by

Read the full article

Listed in

Log in to save this article

Abstract

No abstract available

Article activity feed

  1. Version published to 10.3389/fimmu.2020.560381
  2. ScreenIT

    SciScore for 10.1101/2020.06.02.20120295: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: Leftover sera samples from routine analytical control were employed for the research analysis, after obtaining corresponding informed consent.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Concentration levels were interpolated from the standard curve using a four-parameter logistic (4-PL) curve-fit in Prism8 GraphPad software.
    GraphPad
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The strategy of inhibiting monocyte differentiation has proved useful in avoiding cytokine storm syndrome after CAR-T cell immunotherapy [25], suggesting a possible therapeutic application to COVID-19 immunopathology [26] The present study has several limitations, including the relatively low numbers of patients tested and the interference of tocilizumab and corticoids in ICU patients’ results. However, these preliminary results are strongly suggestive of an important implication of monocyte-macrophage in COVID-19 immunopathology, as highlighted by the correlations found between these biomarker levels and inflammatory parameters. Further studies using broader series are needed to confirm our findings. In summary, our data underscore the preponderant role of monocyte and macrophage immune response in COVID-19 immunopathology and provide pointers for future interventions in drug strategies and monitoring plans for these patients.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.06.02.20120295v1 on medRxiv