Lactobacillus acidophilus: Boosting Immunity Through IL-6 Induction

Probiotics, live microorganisms that promote health when consumed in adequate amount and ensure the balance of bacterial composition in the digestive system, suppress harmful pathogenic bacteria, with overall implications for animal and human health, welfare and performance. However, a lot remains unclear about their functional mechanisms. In this study, 14 uncharacterized proteins of _Lactobacillus acidophilus_ were analyzed for subcellular localization, structural and safety profiling and interleukin-6-(IL-6)-inducing potential. Aliphatic index scores were generally high, ranging between 138.39 (LBA1705) and 78.39 (LBA1825). The instability index scores were less than 40 for all the query proteins except for LBA0995. All the proteins produce immunogenic IL-6-inducing peptides except for LBA0037, LBA1825 and LBA1788. The findings provide insight into understanding the functional mechanism of probiotic _Lactobacillus, _laying a strong foundation for more experimental studies_._