High-Frequency Self-Testing by Schoolteachers for Sars-Cov-2 Using a Rapid Antigen Test: Results of the Safe School Hesse study
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2020.12.04.20243410: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study protocol was approved by the ethics board of the University Hospital, Goethe University, Frankfurt am Main, Germany (No. 20-899). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources In the laboratory (Institute for Medical Virology, Goethe University Frankfurt), a SARS-CoV-2 RT-PCR was performed, using either Roche Cobas® SARS-CoV-2 (Roche diagnostics, Basel, Switzerland), Alinity m® SARS-CoV-2 Assay (Abbott Laboratories, Abbott Park, IL, USA) or Xpert® Xpress SARS-CoV-2 (Cepheid, Sunnyvale, CA, USA). Abbott Laboratoriessuggeste…SciScore for 10.1101/2020.12.04.20243410: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study protocol was approved by the ethics board of the University Hospital, Goethe University, Frankfurt am Main, Germany (No. 20-899). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources In the laboratory (Institute for Medical Virology, Goethe University Frankfurt), a SARS-CoV-2 RT-PCR was performed, using either Roche Cobas® SARS-CoV-2 (Roche diagnostics, Basel, Switzerland), Alinity m® SARS-CoV-2 Assay (Abbott Laboratories, Abbott Park, IL, USA) or Xpert® Xpress SARS-CoV-2 (Cepheid, Sunnyvale, CA, USA). Abbott Laboratoriessuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has several limitations. All participants were educators in primary or secondary schools, and therefore had a higher education. Not all teachers at the schools that participated in the study performed the test every 48 hours throughout the entire study period, and not all teachers from the schools participated in the study. Furthermore, no students from these schools were tested, and transmissions in the participating schools were not examined. As no students were enrolled in the study, we also do now know whether the approach of high-frequency, self-performed testing is beneficial in children. In conclusion, we could demonstrate that a high frequency, self-performed antigen tests by teachers can result in the detection of individuals who are probably infectious, and therefore could contribute to making the school environment safer during the pandemic. Testing for SARS-CoV-2 is especially important when symptoms are present, which may also be mild or atypical. As infections may also be missed by use of an antigen test, all non-pharmaceutical interventions should be applied regardless of the use of rapid antigen tests. The authors received positive feedback from the study participants throughout the study, a large majority of whom experienced the study participation with regular testing for SARS-CoV-2 to be reassuring when working in schools during the pandemic.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-
SciScore for 10.1101/2020.12.04.20243410: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement The study protocol was approved by the ethics board of the University Hospital, Goethe University, Frankfurt am Main, Germany (No. 20-899). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources In the laboratory (Institute for Medical Virology, Goethe University Frankfurt), a SARS-CoV-2 RT-PCR was performed, using either Roche Cobas® SARS-CoV-2 (Roche diagnostics, Basel, Switzerland), Alinity m® SARS-CoV-2 Assay (Abbott Laboratories, Abbott Park, IL, USA) or Xpert® Xpress SARS-CoV-2 (Cepheid, Sunnyvale, CA, USA). …SciScore for 10.1101/2020.12.04.20243410: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement The study protocol was approved by the ethics board of the University Hospital, Goethe University, Frankfurt am Main, Germany (No. 20-899). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources In the laboratory (Institute for Medical Virology, Goethe University Frankfurt), a SARS-CoV-2 RT-PCR was performed, using either Roche Cobas® SARS-CoV-2 (Roche diagnostics, Basel, Switzerland), Alinity m® SARS-CoV-2 Assay (Abbott Laboratories, Abbott Park, IL, USA) or Xpert® Xpress SARS-CoV-2 (Cepheid, Sunnyvale, CA, USA). Abbott Laboratoriessuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
This study has several limitations. All participants were educators in primary or secondary schools, and therefore had a higher education. Not all teachers at the schools that participated in the study performed the test every 48 hours throughout the entire study period, and not all teachers from the schools participated in the study. Furthermore, no students from these schools were tested, and transmissions in the participating schools were not examined. As no students were enrolled in the study, we also do now know whether the approach of high-frequency, self-performed testing is beneficial in children. In conclusion, we could demonstrate that a high frequency, self-performed antigen tests by teachers can result in the detection of individuals who are probably infectious, and therefore could contribute to making the school environment safer during the pandemic. Testing for SARS-CoV-2 is especially important when symptoms are present, which may also be mild or atypical. As infections may also be missed by use of an antigen test, all non-pharmaceutical interventions should be applied regardless of the use of rapid antigen tests. The authors received positive feedback from the study participants throughout the study, a large majority of whom experienced the study participation with regular testing for SARS-CoV-2 to be reassuring when working in schools during the pandemic. Appendix Characterization of all true positive, false positive and false negative antigen tests results d...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.
-
