Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose
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SciScore for 10.1101/2021.09.15.21263633: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. First, the 1,609 individuals who comprise the base cohort of our analyses may not be representative of the vaccinated population in Israel or globally. Nevertheless, the changes observed in self-reported reactions and well-being indicators as well as objective physiological indicators recorded by the …
SciScore for 10.1101/2021.09.15.21263633: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. First, the 1,609 individuals who comprise the base cohort of our analyses may not be representative of the vaccinated population in Israel or globally. Nevertheless, the changes observed in self-reported reactions and well-being indicators as well as objective physiological indicators recorded by the smartwatches were statistically significant and consistent with each other. Moreover, the reaction types, frequency and duration we observed for the first and second dose were similar to those observed in the BNT162b2 mRNA vaccine clinical trials (23). In addition, a clear pattern of returning to baseline levels was observed within 72 hours post inoculation in all examined measures. Lastly, although the sample size was limited, trends were consistent regardless of age group, gender, and the existence of underlying medical conditions. Second, we did not explicitly control for the effects of the observational trial setting (i.e., participating in a trial, wearing a smartwatch, potential concerns regarding the vaccine, etc.). Any effects of the observational trial setting should, in principle, have similar impacts on our analysis of each of the three vaccine doses. However, since we found no deviations in most measurements from baseline levels in the subset of participants who received their first dose, we believe the changes observed after the second and third doses arise from an actual reaction to the vaccine. Third, the smartwatches used to obta...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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