Interventions to Disrupt Coronavirus Disease Transmission at a University, Wisconsin, USA, August–October 2020

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Abstract

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  1. SciScore for 10.1101/2021.05.07.21256834: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsField Sample Permit: All specimens were collected via anterior nasal swabs, and testing was conducted using FDA-authorized real-time reverse transcription polymerase chain reaction (rRT-PCR) tests.
    IRB: Whole Genome Sequencing: Ethical approvals: A waiver of HIPAA Authorization was obtained by the Western Institutional Review Board (WIRB #1-1290953-1) to obtain the clinical specimens for whole genome sequencing.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    24 Epidemiologic data analyses were performed using SAS software, version 9.4 (SAS Institute, Cary, NC), and RStudio, version 1.2.1335 (RStudio Team, Boston, MA).
    SAS
    suggested: (SASqPCR, RRID:SCR_003056)
    SAS Institute
    suggested: (Statistical Analysis System, RRID:SCR_008567)
    RStudio
    suggested: (RStudio, RRID:SCR_000432)

    Results from OddPub: Thank you for sharing your code and data.


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This analysis is subject to limitations. Full lists of off-campus students and staff and their COVID-19 testing histories were not available; therefore, attack rates could only be calculated for students living in on-campus residence halls. Data related to race, ethnicity, and other social determinants of health that may have impacted case counts and disease progression were not examined. Occupancy levels remained fluid throughout the semester, but available data used for residence hall census calculations represented a single point in time at the end of the outbreak, when occupancy was lower than at the start of the semester. UW-Madison’s rapid implementation of a series of interventions targeting different populations limits our ability to determine the effectiveness of each individual intervention. Specimens from students living in Residence Halls A and B were initially targeted for sequencing to understand transmission patterns within and across these housing units. Therefore, our sequencing results should not be generalized to the campus at large, as transmission events may have occurred after campus-related clusters outside of Residence Halls A and B that we did not characterize. In addition, sequencing of Dane County specimens in Nextstrain represented a small proportion of the total number infections within the county (about 3.0%) and were sampled non-randomly among clients of one large testing provider. Therefore, it is possible that descendant infections from UW-Mad...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.