Direct and Indirect Effectiveness of mRNA Vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 in Long-Term Care Facilities, Spain
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SciScore for 10.1101/2021.04.08.21255055: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study obtained approval from the research ethics committee at the Instituto de Salud Carlos III (CEI PI 98_2020). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Some limitations to study results could relate to the before-after comparison. Even though we tried to minimize it, …
SciScore for 10.1101/2021.04.08.21255055: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study obtained approval from the research ethics committee at the Instituto de Salud Carlos III (CEI PI 98_2020). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Some limitations to study results could relate to the before-after comparison. Even though we tried to minimize it, residual confounding due to higher incidence during the third epidemic wave and possibly, to the relaxation of the isolation of LTCF during the Christmas season, with higher number of day-outs and visits, may be present and could underestimate the protection of the vaccine. This underestimation of the effect of the vaccine could maybe explain that the effect of natural infection in the non-vaccinated group was found higher than the effect of the vaccine. The conservative direction of the possible bias is shown by the bias indicator analysis (supplementary material). In conclusion, our results confirm the effectiveness of vaccination in institutionalized elderly population, endorse the policy of universal vaccination in this setting, including in people with previous infection, and suggest that even non-vaccinated individuals benefit from indirect protection. Further questions include the duration of protection in this population and according to previous infection, and the severity of infection, which could not be measured in this study.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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