Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France
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SciScore for 10.1101/2020.06.21.20132449: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: All the participants gave written informed consent for research according to protocols approved by the institutional review board of Strasbourg University Hospitals (CE-2020-34).
IRB: All the participants gave written informed consent for research according to protocols approved by the institutional review board of Strasbourg University Hospitals (CE-2020-34).Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Three serological assays were used to determine the presence of anti-SARS-CoV-2 antibodies in index patients and contacts: i) The Abbott … SciScore for 10.1101/2020.06.21.20132449: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: All the participants gave written informed consent for research according to protocols approved by the institutional review board of Strasbourg University Hospitals (CE-2020-34).
IRB: All the participants gave written informed consent for research according to protocols approved by the institutional review board of Strasbourg University Hospitals (CE-2020-34).Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Three serological assays were used to determine the presence of anti-SARS-CoV-2 antibodies in index patients and contacts: i) The Abbott Architect SARS-CoV-2 IgG is a chemiluminescent microparticle immunoassay for detection of IgG against the SARS-CoV-2 nucleoprotein; and ii) The Euroimmun Anti-SARS-CoV-2 Assay is an enzyme-linked immunosorbent assay (ELISA) for the detection of IgG against the SARS-CoV-2 S1 domain of the spike protein including the immunologically relevant receptor binding domain (RBD). Anti-SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources Three serological assays were used to determine the presence of anti-SARS-CoV-2 antibodies in index patients and contacts: i) The Abbott Architect SARS-CoV-2 IgG is a chemiluminescent microparticle immunoassay for detection of IgG against the SARS-CoV-2 nucleoprotein; and ii) The Euroimmun Anti-SARS-CoV-2 Assay is an enzyme-linked immunosorbent assay (ELISA) for the detection of IgG against the SARS-CoV-2 S1 domain of the spike protein including the immunologically relevant receptor binding domain (RBD). Abbott Architectsuggested: (Abbott ARCHITECT i1000sr System, RRID:SCR_019328)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.06.21.20132449: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement All the participants gave written informed consent for research according to protocols approved by the institutional review board of Strasbourg University Hospitals (CE-202034). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources They all developed anti-SARS-CoV-2 antibodies and a significant T cell response detectable up to 69 days after symptom onset. anti-SARS-CoV-2suggested: (Abcam Cat# ab272854, AB_2847844)Software and Algorithms Sentences Resources Three serological assays were … SciScore for 10.1101/2020.06.21.20132449: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement All the participants gave written informed consent for research according to protocols approved by the institutional review board of Strasbourg University Hospitals (CE-202034). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources They all developed anti-SARS-CoV-2 antibodies and a significant T cell response detectable up to 69 days after symptom onset. anti-SARS-CoV-2suggested: (Abcam Cat# ab272854, AB_2847844)Software and Algorithms Sentences Resources Three serological assays were used to determine the presence of anti-SARS-CoV-2 antibodies in index patients and contacts: i) The Abbott Architect SARS-CoV-2 IgG is a chemiluminescent microparticle immunoassay for detection of IgG against the SARS-CoV-2 nucleoprotein; and ii) The Euroimmun Anti-SARS-CoV-2 Assay is an enzyme-linked immunosorbent assay (ELISA) for the detection of IgG against the SARS-CoV-2 S1 domain of the spike protein including the immunologically relevant receptor binding domain (RBD). Abbott Architectsuggested: (Abbott ARCHITECT i1000sr System, SCR_018371)Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from OddPub: We did not find a statement about open data. We also did not find a statement about open code. Researchers are encouraged to share open data when possible (see Nature blog).
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.
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