To Measure the Association between C Reactive Proteins, Vitamin E and Uric Acid in Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized bysynovial inflammation and joint erosion, often leading to systemic complications andreduced quality of life. Vitamin E, a crucial antioxidant, may play a significant role inreducing inflammation in RA. Additionally, uric acid levels, implicated in immuneregulation and inflammation, will be assessed for their association with RA progression.This study aims to investigate the levels of C-reactive protein (CRP), uric acid, and vitaminE with RA compared to healthy individuals.This observational case-control study was conducted in the RheumatologyDepartment of Fatima Memorial Hospital, Lahore, with the aim of investigating theassociation between CRP, Vitamin E, and uric acid levels in rheumatoid arthritis (RA)patients compared to healthy individuals. A total of 60 participants were examined for thestudy, consisting of 30 clinically diagnosed RA patients (case group) and 30 healthyindividuals (control group) with no history of inflammatory or autoimmune diseases. Bloodsamples were collected under standardized conditions from each participant, ensuringconsistency in sample handling and processing. Statistical analysis was performed usingSPSS version 26 to compare the mean values between the case and control groups.Independent t-tests were performed to determine the significance of differences inbiomarker levels between the groups, while Pearson correlation analysis was conducted toexamine the relationships between CRP, vitamin E, and uric acid levels.The results showed that the mean CRP levels were significantly higher in the casegroup (8.17 mg/dL) compared to the control group (3.40 mg/dL), indicating elevatedinflammation in RA patients. On the other hand, vit E levels were significantly lower inthe case group (2.67 mg/L) compared to the control group (4.20 mg/L), suggestingoxidative stress in RA. Uric acid levels were slightly higher in the case group (5.22 mg/dL)compared to the control group (4.53 mg/dL). A positive correlation was observed betweenCRP and uric acid levels, while a negative correlation was found between CRP and vitaminE levels, highlighting the potential interactions between these biomarkers in RA.This study determines the association between elevated CRP and uric acid levels,and reduced vitamin E levels in RA patients, suggesting that inflammation and oxidative stress play significant roles in the pathogenesis of RA. These findings highlight theimportance of monitoring these biomarkers in RA management and may offer insights intopotential therapeutic targets to mitigate disease progression.