Envisioning a Transformative, AI-Driven Healthcare Paradigm for Kerala and India by 2035: A Policy Blueprint for Seamless Integration of Predictive Analytics, Personalized Preventive Care, Immersive Digital Mental Health Solutions, and Autonomous Primary Healthcare Delivery to Achieve Universal, Inclusive, and Resilient Health Systems.

The global health sector faces escalating demands, necessitating innovative strategies to ensure equitable, accessible, and resilient healthcare delivery. This document delineates a comprehensive policy blueprint for Kerala, designed to leverage advanced artificial intelligence (AI), machine learning (ML), and immersive technologies to fundamentally reshape its healthcare landscape by 2035, serving as a scalable model for India. The analysis outlines objectives centered on augmenting primary healthcare access, enhancing mental health support, and fortifying preventive care, aligning with India’s National Digital Health Mission and broader global innovation trajectories. A systematic review of existing literature, coupled with thematic analysis, informs the identification of critical policy gaps and technological opportunities. Key qualitative findings underscore the transformative capacity of AI-powered predictive models for risk identification and resource optimization, the potential for genomics-enabled personalized prevention, and the efficacy of immersive technologies in delivering stigma-free mental health interventions. The analysis also highlights the imperative for robust, interoperable digital infrastructures and community-embedded autonomous healthcare solutions. Policy implications emphasize the need for integrated governance models, ethical frameworks for data use, and strategies for equitable technology deployment. The proposed framework includes pragmatic implementation pathways, detailing institutional roles, stakeholder engagement, and resource allocation. Evaluation strategies, incorporating key performance indicators (KPIs) and continuous feedback loops, are also presented to ensure adaptive policy refinement. This approach offers a foundational strategy for achieving universal, inclusive, and resilient health systems in Kerala, with significant implications for national healthcare evolution. The methodology, a structured textual systematic review augmented by thematic synthesis, provides a transparent and replicable approach to policy-relevant evidence generation.