Shaping Public Health Policy in Personalised Prevention: The multidimensional PROPHET Framework

  1. Astrid Vicente
  2. Angelica Valz Gris
  3. Cristina Costa
  4. Maria Luis Cardoso
  5. Alexandra Costa
  6. Fátima Lopes
  7. Pragathy Kannan
  8. Markus Perola
  9. Roberta Pastorino
  10. Angelo Pezzullo
  11. Stefania Boccia
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Abstract

There is currently no widely accepted framework to guide decision-making for preventive approaches using genetic and genomic technologies. In the context of the PROPHET project, we developed a multidimensional framework integrating Health Technology Assessment (HTA) and Health Impact Assessment (HIA), complemented by a monitoring phase to assess the impact of policies implementing personalised prevention interventions. This integrated approach links technical, clinical, and societal dimensions, supporting prevention strategies that are effective, equitable and sustainable. The PROPHET framework supports policy makers in the equitable and efficient implementation of personalised prevention policies at scale.

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  1. Version published to 10.31235/osf.io/2nv5e_v1 on OSF Preprints