Instinctual Refinement Therapy for Complex Trauma: A Proof-of-Concept Case Series and Research Roadmap

Objective: Contemporary trauma therapies often target cognitive schemas and explicit memories, potentially neglecting the disruption of evolutionarily conserved instinctual systems by early adverse experiences. This study provides a preliminary evaluation of Instinctual Refinement Therapy (IRT), a novel protocol designed to directly address these instinctual disruptions.Method: A retrospective case series analysis was conducted on 30 clinical cases (70% female; Mage = 32.4 years) with diverse, often treatment-resistant presentations (e.g., anxiety, mood, and psychotic disorders). IRT integrates predictive processing and memory reconsolidation frameworks to recalibrate maladaptive instinctual pathways. Treatment response was assessed via pre-post clinical measures and rates of clinical improvement.Results: Preliminary analysis indicated a high rate of clinical improvement (94%; 28/30 cases), achieved over a mean of 54.2 sessions. Large pre-post effect sizes were observed across standardized measures, with a mean aggregate effect size of *d* = 2.1. Therapeutic gains were maintained at follow-up in 80% of assessed cases. The distribution of anxiety disorders, more prevalent in females (71%), aligned with epidemiological trends.Conclusion and Implications: These preliminary findings suggest IRT is a feasible and potentially effective intervention for complex, treatment-resistant trauma presentations. The results warrant systematic investigation to establish its efficacy. This paper provides a detailed description of the IRT protocol, initial clinical data, and a essential research roadmap to guide future controlled trials and neurobiological investigations into its proposed mechanisms of action.Keywords: Instinctual Refinement Therapy, complex trauma, predictive processing, memory reconsolidation, case series, transdiagnostic, treatment development.