High Prevalence of Both Previous Infection with SARS-CoV-2 and Persistent Symptoms
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SciScore for 10.1101/2021.07.08.21260201: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: It was approved by the Human Subjects Committee at the University of Georgia (Version 00000889, Project 00003338).
Consent: All participants gave written informed consent prior to participation.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources IgA antibodies were detected using horseradish peroxidase (HRP)-conjugated goat anti-human IgA detection antibody (Southern Biotech, Birmingham, AL, USA) at a 1:4000 dilution, and incubated for 90 min at 37°C. anti-human IgAsuggested: NoneDetermination of cutoffs for defining a positive antibody test: The ELISA test for SARS-CoV-2 IgA … SciScore for 10.1101/2021.07.08.21260201: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: It was approved by the Human Subjects Committee at the University of Georgia (Version 00000889, Project 00003338).
Consent: All participants gave written informed consent prior to participation.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources IgA antibodies were detected using horseradish peroxidase (HRP)-conjugated goat anti-human IgA detection antibody (Southern Biotech, Birmingham, AL, USA) at a 1:4000 dilution, and incubated for 90 min at 37°C. anti-human IgAsuggested: NoneDetermination of cutoffs for defining a positive antibody test: The ELISA test for SARS-CoV-2 IgA antibodies was administered simultaneously with a serum test for SARS-CoV-2 IgG antibodies as a reference standard to 18 volunteers. SARS-CoV-2 IgAsuggested: NoneSARS-CoV-2 IgGsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A limitation of our study is the fact that this was not a random sample of students. However, we did deliberately sample a broad range of classes, levels, and colleges to generate a diverse sample, and we also adjusted our estimate to the year and sex distribution of the university as a whole. While the saliva test is less accurate than serology, it was more practical for rapid data collection in a classroom setting, and our analysis was able to adjust for the lack of sensitivity using a validated approach. Assessment of risk factors was by self-report and there may be a degree of social desirability bias to some of the questions, such as adherence to mask-wearing and attending parties or bars. Finally, we did not assess the type or severity of persistent symptoms. Conclusions: We estimate that over 40% of students at our university were infected with SARS-CoV-2, and that many were asymptomatic. Risk factors for infection include having an infected roommate and male sex, and approximately 11% with a symptomatic infection were experiencing persistent symptoms months later. Given low vaccination rates among young people, and the increasing prevalence of more contagious variants, mandating vaccination prior to return to campus is needed to prevent resurgence of the infection and harm to students, staff and faculty, especially as many universities have abandoned other protective measures.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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