A Hypothetical Approach to Enhancing Protein Bioavailability via Enzymatic Digestion and Sublingual Deliver

This paper proposes a novel protein delivery strategy utilizing externally enzymatically digested proteins—specifically small peptides and amino acids—administered via the sublingual route. The hypothesis aims to bypass the gastrointestinal tract and hepatic first-pass metabolism, which are known to limit the bioavailability of orally consumed proteins and peptides. This approach could significantly increase the bioavailability of key nutrients and therapeutic peptides, offering a faster and more efficient alternative to traditional oral delivery methods. Potential applications include sports medicine—where rapid post-exercise recovery is critical—and clinical nutrition, particularly for patients with impaired digestion or absorption. The theoretical feasibility of this method is supported by emerging studies on sublingual peptide uptake and advancements in mucoadhesive and nanoparticle-based formulation technologies. This hypothesis invites further scientific exploration into alternative, more efficient protein supplementation systems.