OCD ： Compulsive behaviors are closely related to needs and norepinephrine (NE)

Results: Currently, I have regained approximately 95% control over compulsive behaviors, with significant restoration of cognitive flexibility. Key findings include: 1) The motivation for all voluntary human behaviors arises from two core drives: the pursuit of need satisfaction and the avoidance of need loss, with compulsive behaviors exclusively driven by the latter. 2) Behaviors are not directly triggered by cognition but are mediated through a valuation system that converts cognitive information into interoceptive signals, which subsequently drive action. 3) The human brain processes emotions and motivations in the following ways: performing perceptual inference, performing perceptual reasoning (Cognitive Reasoning), adjusting expected needs, planning motor sequences, and planning compensatory motor sequences. 4) The norepinephrine (NE)-mediated neurophysiological responses in the cerebral cortex demonstrate marked consistency with OCD symptomatology, leading us to hypothesize that this mechanism constitutes the primary underlying mechanism responsible for cognitive inflexibility in OCD patients. Conclusion: These findings can significantly optimize cognitive-behavioral therapy (CBT) and exposure and response prevention (ERP) therapy, thereby facilitating broader accessibility to ERP treatment, specifically offering substantial therapeutic gains for individuals with treatment-resistant severe OCD. and will provide important insights for researchers to reveal the pathogenesis of OCD and explore the mechanisms underlying the generation of behaviors.