The Universal Law of Life Systems: Entropy Resistance and the Nature of Living Systems

The quest to define life remains one of the most profound scientific and philosophicalchallenges. Traditional biological definitions, anchored in terrestrial biochemistry andcellular structures, risk excluding forms of life that may emerge under radically differentphysical conditions. In this work, I propose a universal, substrate-independent defini-tion: life is any system that sustains a positive rate of entropy resistance, formalizedmathematically asR(t) =−dS/dt > 0Under this framework, life is not characterized by its molecular composition, but by itspersistent maintenance of low-entropy, high-information states against the backdrop ofthe Second Law of Thermodynamics.By reframing life as a thermodynamic and informational phenomenon, I unify ter-restrial, synthetic, and potential extraterrestrial lifeforms under a single physical princi-ple. This Universal Law of Life Systems offers a predictive foundation for astrobiology,synthetic biology, and the emerging field of entropy-based life detection. It invites are-examination of the nature of existence itself: viewing life not as an anomaly, butas an inevitable thermodynamic phenomenon wherever complexity, energy flow, andinformation resistance intersect.