Integrating Virtual Reality and Cognitive Neuroscience: Enhancing Learning Outcomes Through α5-GABAA Receptor Modulation

Virtual reality (VR) has emerged as a transformative tool in healthcare and educational research, offering immersive environments for clinical training and cognitive neuroscience investigations. This study examines the intersection of VR applications and cognitive neuroscience, emphasizing the role of VR in modulating neurophysiological pathways critical for learning and adaptation. Specifically, we focus on the α5-GABAA receptor, which is instrumental in mediating synaptic plasticity and memory consolidation processes. Recent findings suggest that VR-based interventions can influence α5-GABAA receptor activity, thereby enhancing cognitive outcomes and alleviating stress associated with high-stakes clinical scenarios. By integrating VR with neurobiological mechanisms, such as the modulation of inhibitory neurotransmission, this review explores its potential to bridge the gap between theoretical learning and practical applications in healthcare education. The findings aim to establish a framework for designing VR experiences that optimize both user engagement and neurocognitive efficacy.