Single Cell Analysis for Alzheimers Integrating Transcriptomics and Synthetic Biology

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterised by progressive cognitive decline. Single-cell transcriptomics has unveiled the complex cellular landscape of Alzheimer’s disease (AD), revealing distinct disease-associated cell states and gene expression profiles. This information provides a crucial foundation for leveraging the power of synthetic biology to develop targeted interventions. This paper explores the integration of these two fields, focusing on applications such as: 1) using transcriptomic data to design cell-type-specific synthetic constructs; 2) modelling and manipulating disease-relevant cell-cell interactions; and 3) engineering therapeutic cells for targeted drug delivery or immunomodulation. We discuss the potential of this integrated approach to advance our understanding of AD pathogenesis and pave the way for innovative therapeutic strategies, while also considering the associated challenges and future directions.