Topologically Associating Domains in 3D Chromatin Organization

The spatial organization of the genome within the nucleus is crucial in regulating gene expression, DNA replication, and other cellular processes. Topologically Associating Domains (TADs) is a important feature, and is the compartmentalization of the genome into discrete regulatory clusters. The review goes through biophysical and mathematical models used to understand TAD formation and chromatin folding, and has a focus on polymer physics and contact probability scaling. The discussion of scaling laws are present where the decay exponent provides insights into the polymer conformation. Additionally, there is the examination of mechanistic models like loop extrusion to highlight compatibility with potential Hi-C data [01].