Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: design, methods and initial findings of the Germina cohort study
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This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B=0.29), epigenetics (B=0.11), EEG theta (B=0.14) and beta activity (B=0.11), and microbiome functional pathways (B=0.08) domains, and infant development, suggesting potential interventions to prevent impairments.
