NeuroGenesis Nexus: A Theoretical Framework for Nano-Enhanced, Stem Cell-Integrated Brain-Computer Interfaces for Neural Restoration

The NeuroGenesis Nexus presents a theoretical framework that combines brain-computer interfaces (BCIs) with nanomedicine and regenerative stem cell therapies to develop a complete system for neural restoration and enhancement. The proposed vision works to overcome the present-day neurotechnological restrictions in treating traumatic brain injuries and spinal cord injuries, as well as neurodegenerative disorders. The core principle of the Nexus depends on nanobots functioning as therapeutic agents and data transporters, which work together with customised stem cell scaffolds to rebuild neural tissue damage. Nanobots under the direction of the Regenerative Intelligence Engine (RIE) AI system use patient-specific multi-omic profiles together with environmental stimuli and real-time neuroelectrical activity to deliver customised interventions dynamically. The theoretical framework extends to quantum neurobridges and photonic neuroholography, and self-evolving neural biospheres.The model uses present-day organoid modelling, gene editing, and neural nanomaterials as foundations to predict future applications, which could transform neuroscience and medical practices. The proposed concept relies on biological pathways that exist in nature and matches current developments in systems biology, machine learning and bioengineering.The manuscript describes the Nexus system architecture, together with component interactions and translational pathways and ethical considerations. The NeuroGenesis Nexus represents a revolutionary change because it shifts from passive neural restoration to active neuroevolution.