Synergistic Rejuvenation: A Comprehensive Review of Combination Therapies with Botulinum Toxin and Dermal Fillers in Aesthetic Medicine

This literature review synthesizes current scientific evidence on the synergistic effects of combination therapies using botulinum toxin (BoNT-A) and dermal fillers in aesthetic medicine. The increasing demand for minimally invasive facial rejuvenation has led to the widespread use of these treatments, often in combination to address both dynamic wrinkles and volume loss. This review explores the mechanisms behind the enhanced outcomes observed with combination therapy, its efficacy and safety across different facial regions, and how it compares to monotherapies. The methodology involved a comprehensive search of major electronic databases for relevant articles published within the last 10 years. The findings indicate that combining BoNT-A and fillers can lead to superior aesthetic results, potentially longer-lasting effects, and higher patient satisfaction by targeting different aspects of facial aging. While the safety profile is generally favorable, the review identifies areas for future research, including a deeper understanding of the underlying synergistic mechanisms and the optimization of treatment protocols for diverse patient populations. The conclusion highlights the value of combination therapy as a comprehensive approach to facial rejuvenation in aesthetic practice.