Quercetin-loaded Biocomposites for Wound Healing Applications

Skin plays a vital role in protecting the human body from hazardous stimuli such as oxidizing agents and inflammatory triggers. To improve the skin's defense mechanisms against endogenous and exogenous damage, the administration of antioxidants can be a promising strategy. Quercetin (Que) is a well-known flavonoid with prominent antioxidant, anti-inflammatory, anti-aging, and anti-microbial properties, contributing to better wound healing and skin care. However, its poor solubility has limited the penetration capacity into the skin. To overcome this limitation, various formulations and composite strategies have been developed to efficiently increase its cutaneous penetration. Here we have provided an overview of the underlying mechanisms of wound healing with a focus on the therapeutic capability and performance of quercetin in every stage of this process. In the end, a range of drug delivery approaches that promote the transdermal penetration of Que has been discussed.