SARS-CoV-2 variant B.1.1.7 susceptibility and infectiousness of children and adults deduced from investigations of childcare centre outbreaks, Germany, 2021
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Abstract
We investigated three SARS-CoV-2 variant B.1.1.7 childcare centre and related household outbreaks. Despite group cohorting, cases occurred in almost all groups, i.e. also among persons without close contact. Children’s secondary attack rates (SAR) were similar to adults (childcare centres: 23% vs 30%; p = 0.15; households: 32% vs 39%; p = 0.27); child- and adult-induced household outbreaks also led to similar SAR. With the advent of B.1.1.7, susceptibility and infectiousness of children and adults seem to converge. Public health measures should be revisited accordingly.
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SciScore for 10.1101/2021.05.12.21256608: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:We acknowledge the following limitations: First, because not everyone was tested, we may have underestimated the true SAR. However, symptom monitoring during quarantine was in place and would have led to immediate testing. Second, in households, …
SciScore for 10.1101/2021.05.12.21256608: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:We acknowledge the following limitations: First, because not everyone was tested, we may have underestimated the true SAR. However, symptom monitoring during quarantine was in place and would have led to immediate testing. Second, in households, asymptomatic persons may be the true PC, and cases outside the family may have infected a family member independently from the assumed household’s PC. Even if these possibilities may be true in single households it is unlikely to distort gravely the overall picture. In summary, our investigation confirms increased transmissibility of B.1.1.7. In addition, the data presented suggest that both susceptibility and infectiousness of children 1-5-years-old is substantially higher compared to the pre-VOC era, and may be converging to those among adults. To prevent individual daycare center outbreaks, or at least limit outbreak size, measures need to be revisited, including non-pharmaceutical measures, early closure should be considered when cases are occurring and vaccination of educators should be promoted.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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