COVID-19 Diagnosis based on Taste Disorders: A Case-Control Study
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SciScore for 10.1101/2020.05.31.20118380: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Finally, based on the above criteria, the concentrations with the highest diagnostic values were selected from the set of the previously discussed concentrations, along with the names assigned to the tastant tablets: Main study: The main study was conducted from April to May 2020 on 92 students from Warsaw, Poland (all of those living in a dormitory) who fulfilled the inclusion (confirmed SARS-CoV-2 infection, aged over 18) and exclusion criteria (lack of informed consent, smell or taste disturbances lasting more than three months on the day of the test, any neurological disease, any disease or factor that in the opinion of an investigator may … SciScore for 10.1101/2020.05.31.20118380: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Finally, based on the above criteria, the concentrations with the highest diagnostic values were selected from the set of the previously discussed concentrations, along with the names assigned to the tastant tablets: Main study: The main study was conducted from April to May 2020 on 92 students from Warsaw, Poland (all of those living in a dormitory) who fulfilled the inclusion (confirmed SARS-CoV-2 infection, aged over 18) and exclusion criteria (lack of informed consent, smell or taste disturbances lasting more than three months on the day of the test, any neurological disease, any disease or factor that in the opinion of an investigator may influence the tests) and who provided signed informed consent. Randomization not detected. Blinding not detected. Power Analysis However, a post-hoc power calculation was performed using a Chi-square test (RxC) for a population of 88 participants. Sex as a biological variable This study was conducted on 25 young, healthy male adults with a median age of 21.11 years (min 19, max 26) with no concomitant diseases, who tested negative for SARS-CoV-2 according to the PCR results of a nasopharyngeal swab test. Table 2: Resources
Software and Algorithms Sentences Resources 16 The GeneFinder COVID-19 PLUS RealAmp Kit was used, detecting RdRp, E and N genes, with a sensitivity of 10 copies of these genes, and cut-off point of ≤43 cycles for a positive result. GeneFindersuggested: (GENEFINDER, RRID:SCR_009190)Statistical Analysis: Statistical analyses were conducted with PQStat version 1.8.0.392 and IBM SPSS Statistic version 21. SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has some limitations. A relatively low number of patients implies a validation in the bigger population, which is planned in the future. However, one of the strengths of this study is that it was performed on a uniform, young and otherwise healthy population living in a similar environment, with a comparable examined and control group. The fact that the majority of subjects in the examined and control group in this study were men can be regarded as a limitation. However, as SARS-CoV-2 positive men seem to have gustatory dysfunction more rarely that women, the results could be even more reliable in women and in the general population.5 Another limitation is the limited accuracy of RT-PCR tests, which are the gold standard of COVID-19 diagnosis. To confirm the results of a PCR test, each patient underwent SARS-CoV-2 tests twice. In one case, a patient who initially received a negative diagnosis subsequently obtained a confirmed positive result. In summary, the pandemic situation not only checks the state’s health security system but above all affects the sense of security of the individual. Regardless of psychophysical resilience, it destabilizes functioning, especially in the absence of information regarding potential infection. Hence, tests, especially those widely available, are crucial in satisfying the basic human needs related to their health safety. At present, the gold standard for the detection of SARS-CoV-2 infection, according to the WHO, is RT-PCR examina...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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