Result Turnaround Time of RT-PCR for SARS-CoV-2 is the Main Cause of COVID-19 Diagnostic Delay: A Country-Wide Observational Study of Mexico and Colombia

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Abstract

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  1. SciScore for 10.1101/2021.06.16.21259046: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study has several limitations. It is observational and used repurposed data, and as such it is difficult to ascertain the precision of initial symptom date and diagnosis date, but both countries use this data to make public health decisions and thus our results are applicable. The fact that Colombia does not share information on every tested individual is also a limitation, as positive individuals in that country could arrive at a different time to testing, even if our exploratory analysis in Mexico does not show this. Selection bias might also present, since both countries do only limited testing, with Mexico testing only one of 10 ambulatory patients and all hospitalized. We are unable to make conclusions regarding symptomatic patients who do not search for care and asymptomatic individuals, as they are not included in the open data (22). This could evidently influence either people’s ability to get tested and the laboratory’s speed to give results, but this is precisely our point. These variables are not accounted for in current testing strategies at both of these countries, and low testing efficiency is a side effect of this. Our study also has several strengths. It conveys information of two countries and a large number of individuals during a significant proportion of the pandemic. Even if data is repurposed, the main variables should not have recall bias affect them in a meaningful way as it is routine information. Thus, diagnostic delays can be adequately quantifi...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


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